7.2 Toxicity Value (Dose-Response Reaction)

The Paracelsus principle — the dose makes the poison (no substance absolutely safe-or- dangerous). The dose-response curve: the threshold's concept (the no-effect level); the increasing response's slope; the LD50 (the lethal dose's 50% — the toxicity's classic measure). The forensic's application: the concentration's interpretation (the therapeutic vs toxic vs lethal ranges); the individual's variation (the age, weight, health, tolerance — the addiction's tolerance); the synergies (the drug combinations — the alcohol-opioid potentiation).